An advanced Sr. Research Specialist is needed to participate in a funded laboratory that uses established mouse models to study the mechanisms contributing to the development of graft-versus-host disease (GVHD) and acute and chronic, non-infectious lung injury that occurs following allogeneic bone marrow transplantation (BMT).
Specific Duties & Responsibilities
Implement GVHD experiments using established murine BMT models including bone marrow transplantation, analysis of mice, and key cellular and molecular immunologic components of the study.
Conduct procedures directly related to the manipulation, transplantation, and examination of animals.
Coordinate harvesting of bone marrow, the T cell depletion of the bone marrow, purification of T cells from spleens, irradiation and injection of recipient animals
Responsible for weekly scoring of mice for signs of graft-versus-host disease.
Participate in post-transplant analysis, including the procurement of organs for fixation and cell suspensions for cell surface staining and intracellular cytokine analysis.
Procure organs for fixation and cell suspensions for cell surface staining and intracellular cytokine analysis (On average, one transplant per week will be performed.)
Collaborate with the Principal Investigator to oversee scientific management of the research laboratory.
Manage independent research projects in collaboration with the Principal Investigator
Identify and select best options for scientific strategies and research development based on literature reviews and collaboration with colleagues.
Develop and validate assays.
Evaluate options and make decisions regarding the purchase of new laboratory equipment.
Contribute to writing of scientific publications and grant applications.
Act as a resource for laboratory techniques for post-doctoral fellow and students and junior technicians
Extracts scientific information from literature/lectures/seminars and translates into productive contributions to lab interests.
Identifies problem areas and proposes and implements plans for solutions.
Draws upon extensive experience and collaborative resources to make decisions.
Make decisions regarding research projects that may require assessment, revision of objectives, or altering scientific direction; considers resources and lab priorities when making decisions.
Exercises authority and intervenes to resolve scientific and administrative issues.
Provides constructive guidance to entry-level and peer lab members in a collegial manner.
Performs constructive self-assessment and solicits feedback from faculty and/or other lab members as appropriate.
Requires advanced professional and scientific communication skills.
Ensures PI is informed of laboratory activities as required, generally with limited reporting opportunities.
Defines clear expectations for all laboratory members.
Develops the laboratory team by interacting with, guiding, and mentoring all laboratory members; provides appropriate constructive guidance and mentoring to senior laboratory members.
Responsible for coordinating the structure within the laboratory to accomplish all activities.
Establishes standards for job expectations and ensures accountability of all laboratory members.
Encourages and inspires team goals and achievements.
Supervises entire laboratory group and/or several projects involving many laboratory members.
Advises and mentors the team by identifying and developing the potential of each laboratory member; develops training exercises to improve overall competency of individuals and the team in the lab.
Incorporates scientific innovations regarding protocol development and research goals.
Proposes ideas for new projects to PI.
Makes changes in laboratory consistent with increasing productivity and decreasing cost.
Acts as central resource for administrative policies; translates policy changes into the laboratory workplace.
Minimum Qualifications
Bachelor's Degree in Biology, Chemistry or related field.
Four years experience in a comparable laboratory performing relevant techniques.
Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.
Preferred Qualifications
Master's in science, Biotechnology or equivalent.
Prior experience with rodent models
Tail vein injections
Molecular and cell biologic techniques (cell culture, ELISA, PCR, western blotting)
Flow cytometry
Classified Title: Sr. Research Specialist Working Title: Sr. Research Specialist Role/Level/Range: ACRP/04/MC Starting Salary Range: Min $47,500 - Max $83,300 Annually ($65,400 budgeted; Commensurate with experience) Employee group: Full Time Schedule: M-F 8am- 4:00pm Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10002936-SOM Onc Pediatric Oncology Personnel area: School of Medicine
Please refer to the job description above to see which forms of equivalency are permitted for this position. If permitted, equivalencies will follow these guidelines: JHU Equivalency Formula: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
**Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.
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