An advanced Sr. Research Specialist is needed to participate in a funded laboratory that uses established mouse models to study the mechanisms contributing to the development of graft-versus-host disease (GVHD) and acute and chronic, non-infectious lung injury that occurs following allogeneic bone marrow transplantation (BMT).

Specific Duties & Responsibilities

• Implement GVHD experiments using established murine BMT models including bone marrow transplantation, analysis of mice, and key cellular and molecular immunologic components of the study.
• Conduct procedures directly related to the manipulation, transplantation, and examination of animals.
• Coordinate harvesting of bone marrow, the T cell depletion of the bone marrow, purification of T cells from spleens, irradiation and injection of recipient animals
• Responsible for weekly scoring of mice for signs of graft-versus-host disease.
• Participate in post-transplant analysis, including the procurement of organs for fixation and cell suspensions for cell surface staining and intracellular cytokine analysis.
• Procure organs for fixation and cell suspensions for cell surface staining and intracellular cytokine analysis (On average, one transplant per week will be performed.)
• Collaborate with the Principal Investigator to oversee scientific management of the research laboratory.
• Manage independent research projects in collaboration with the Principal Investigator
• Identify and select best options for scientific strategies and research development based on literature reviews and collaboration with colleagues.
• Develop and validate assays.
• Evaluate options and make decisions regarding the purchase of new laboratory equipment.
• Contribute to writing of scientific publications and grant applications.
• Act as a resource for laboratory techniques for post-doctoral fellow and students and junior technicians
• Extracts scientific information from literature/lectures/seminars and translates into productive contributions to lab interests.
• Identifies problem areas and proposes and implements plans for solutions.
• Draws upon extensive experience and collaborative resources to make decisions.
• Make decisions regarding research projects that may require assessment, revision of objectives, or altering scientific direction; considers resources and lab priorities when making decisions.
• Exercises authority and intervenes to resolve scientific and administrative issues.

• Provides constructive guidance to entry-level and peer lab members in a collegial manner.
• Performs constructive self-assessment and solicits feedback from faculty and/or other lab members as appropriate.
• Requires advanced professional and scientific communication skills.
• Ensures PI is informed of laboratory activities as required, generally with limited reporting opportunities.
• Defines clear expectations for all laboratory members.
• Develops the laboratory team by interacting with, guiding, and mentoring all laboratory members; provides appropriate constructive guidance and mentoring to senior laboratory members.
• Responsible for coordinating the structure within the laboratory to accomplish all activities.
• Establishes standards for job expectations and ensures accountability of all laboratory members.
• Encourages and inspires team goals and achievements.
• Supervises entire laboratory group and/or several projects involving many laboratory members.
• Advises and mentors the team by identifying and developing the potential of each laboratory member; develops training exercises to improve overall competency of individuals and the team in the lab.
• Incorporates scientific innovations regarding protocol development and research goals.
• Proposes ideas for new projects to PI.
• Makes changes in laboratory consistent with increasing productivity and decreasing cost.
• Acts as central resource for administrative policies; translates policy changes into the laboratory workplace.

• Bachelor's Degree in Biology, Chemistry or related field.
• Four years experience in a comparable laboratory performing relevant techniques.
• Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.

• Master's in science, Biotechnology or equivalent.

• Prior experience with rodent models
• Tail vein injections
• Molecular and cell biologic techniques (cell culture, ELISA, PCR, western blotting)
• Flow cytometry

 Classified Title: Sr. Research Specialist 
Working Title: Sr. Research Specialist   
Role/Level/Range: ACRP/04/MC  
Starting Salary Range: Min $47,500 - Max $83,300 Annually ($65,400 budgeted; Commensurate with experience) 
Employee group: Full Time 
Schedule: M-F 8am- 4:00pm 
Exempt Status: Exempt 
Location: 04-MD:School of Medicine Campus 
Department name: 10002936-SOM Onc Pediatric Oncology 
Personnel area: School of Medicine 

Please refer to the job description above to see which forms of equivalency are permitted for this position. If permitted, equivalencies will follow these guidelines:
JHU Equivalency Formula: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.

**Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.

The successful candidate(s) for this position will be subject to a pre-employment background check. Johns Hopkins is committed to hiring individuals with a justice-involved background, consistent with applicable policies and current practice. A prior criminal history does not automatically preclude candidates from employment at Johns Hopkins University. In accordance with applicable law, the university will review, on an individual basis, the date of a candidate's conviction, the nature of the conviction and how the conviction relates to an essential job-related qualification or function.

The Johns Hopkins University values diversity, equity and inclusion and advances these through our key strategic framework, the JHU Roadmap on Diversity and Inclusion.

Equal Opportunity Employer

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

EEO is the Law
Learn more:
https://www.eeoc.gov/sites/default/files/migrated_files/employers/poster_screen_reader_optimized.pdf

Accommodation Information

If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the Talent Acquisition Office at jhurecruitment@jhu.edu. For TTY users, call via Maryland Relay or dial 711. For more information about workplace accommodations or accessibility at Johns Hopkins University, please visit accessibility.jhu.edu.

Johns Hopkins has mandated COVID-19 and influenza vaccines, as applicable. Exceptions to the COVID and flu vaccine requirements may be provided to individuals for religious beliefs or medical reasons. Requests for an exception must be submitted to the JHU vaccination registry. For additional information, applicants for SOM positions should visit https://www.hopkinsmedicine.org/coronavirus/covid-19-vaccine/ and all other JHU applicants should visit https://covidinfo.jhu.edu/health-safety/covid-vaccination-information/.

The following additional provisions may apply, depending on campus. Your recruiter will advise accordingly.

The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.

Note: Job Postings are updated daily and remain online until filled.

About Johns Hopkins University

Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal...timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.

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