Our laboratory at Northwestern University has an opening for a senior research technologist (mentored position) to assist us with vertebrate animal (mice) care and in vivo tumor models. Our lab has invested in methodologies for high engraftment rates to develop one of the largest patient derived xenograft (PDXs) biorepositories from human tumors. These PDXs will be used to identify gene alterations that affect the survival of mammalian cells to sparsely- (e.g. X-ray, g-rays) and densely-ionizing (heavy particle) irradiation. The overall impact of this work extends beyond its current focus of therapeutic resistance in cancer, including guiding strategies for the protection of mammals from radiation incidents, during space travel, and for the safe colonization of distant planets.

Role

Animal care:

• Provides care for (mice) in a humane, safe, and sanitary manner using appropriate equipment and established procedures
• Observes animals for clinical signs of diseases and monitor tumor growth
• Assists in the preparation of animals for invasive and/or interventional procedures
• Accurately maintains all necessary records to ensure compliance with all applicable regulations, including animal treatments, drug logs and other records as needed
• Administers oral medications and IP injections
• Maintenance of breeder colonies (immunocompromised mice)

 Tissue collection:

• Processing of human tumor samples
• Processing of blood samples collected from patients

Desired Skill Sets

• Prior experience with maintenance and handling of mice colonies is required.